Results
| PMID | 25208225 |
| Gene Name | GSTT1 |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Associated genes | GSTM1, GSTT1 |
|
PLoS One. 2014 Sep 10;9(9):e106761. doi: 10.1371/journal.pone.0106761. Zhu, Haili| Bao, Jiming| Liu, Shuguang| Chen, Qing| Shen, Hong Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.| Department of Urology, Nanfang Hospital, Southern Medic Endometriosis is one of the most frequent benign gynecological disorders. Numerous studies have shown an association between GSTM1 and/or GSTT1 polymorphisms and endometriosis susceptibility. However, these associations remain inconclusive. To derive a more precise estimation, we conducted a comprehensive search to identify all existing studies and then performed a meta-analysis. Electronic literature searches of the PubMed, Chinese Biomedical, and China National Knowledge Infrastructure databases were performed up to December 2013. GSTM1-, GSTT1-, and dual-null genotypes were analyzed independently, and pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated by comparing the null genotype with other genotypes using the random-effects or fixed-effects model. Twenty-five and 16 independent studies on GSTM1 and GSTT1 polymorphisms, respectively, and five GSTM1-GSTT1 interaction analyses were identified and included in this meta-analysis. Both GSTM1- and GSTT1-null genotypes increased risk of endometriosis (OR = 1.54, 95% CI: 1.30-1.83, P<0.001; OR = 1.41, 95% CI: 1.10-1.82, P = 0.007; respectively). Moreover, we found a significant positive association between the dual null genotype GSTM1-GSTT1 and endometriosis susceptibility (OR = 1.33, 95% CI: 1.03-1.72, P = 0.027). This meta-analysis provides evidence that null genotypes of GSTM1 and/or GSTT1 contribute to risk of endometriosis. Further investigations are required to confirm these findings. Mesh Terms: Case-Control Studies| Endometriosis/*enzymology/*genetics| Female| *Genetic Predisposition to Disease| Glutathione Transferase/*genetics| Humans|DA 2015/05/23 06:00 |
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